Professor R. Senthilnithy

Associate Professor in Chemistry

Chemistry
Faculty of Natural Sciences
Head of the Department
Contact:

Colombo Regional Center, 1st floor, Science and Technology building, The Open University of Sri Lanka, Nawala, Nugegoda

Office: 011 2881257, Ext: 257

Email: rsent@ou.ac.lk


Head, Department of Chemistry Faculty of Natural Sciences, The Open University of Sri Lanka, (January 2018 to date)

Senior Lecturer in Chemistry Department of Chemistry, Faculty of Natural Sciences, The Open University of Sri Lanka, (January 2015 to date)

Head, Department of Physical Sciences, Faculty of Applied Sciences, South Eastern University of Sri Lanka (March 2011 to December 2014)

Senior Lecturer in Chemistry, Department of Physical Sciences, Faculty of Applied Sciences, South Eastern University of Sri Lanka, (July 2006 to December 2014)

Lecturer Department of Physical Sciences, Faculty of Applied Sciences, South Eastern University of Sri Lanka, (January 2000 to June 2006)

Area of Specification:
  • Inorganic Chemistry
  • Computational Chemistry
  • Photo Chemistry
Research Intrests:
  • Development of Fluorescence Sensors
  • QM/MM Calculation and Molecular Dynamics Simulation
Affiliations:
  • Fellow – Institute of Chemistry, Ceylon
  • Member – Sri Lanka Association for the Advancement of Science (SLAAS)
  • Chartered Chemist (C. Chem.) for life, Institute of Chemistry, Ceylon

 

 

Programmes Coordination:

B.Sc Degree Programme

Course Coordination:
  • CYU3300 (Basic Principles of Chemistry I)
  • CYU3201 (Basic Principles of Chemistry II)
  • CYU6600 (Advanced Concepts in Chemistry)

Face to Face Lecture delivering for the B.Sc. Special Degree Programme :

  • CYU6600 (Advanced      Coordination Chemistry, Group Theory and Magneto Chemistry),
  • CYU6301 (Inorganic Reaction Mechanism),
  • CYU6304 (ESR Spectroscopy, NQR Spectroscopy and Mossbauer Spectroscopy),
  • CYU5614 (Advanced Thermodynamics)
Awards:
  • NRC Merit Award for Scientific Publications – 2014
  • Presidential Awards for Scientific Research – 2009
  • Presidential Awards for Scientific Research – 2008
  • Presidential Awards for Scientific Research – 2006
  • SEDA Award for Accredited Teacher in Higher Education – 2000
Ongoing Research:

Selected Ph. D, MPhil, M.Sc and B.Sc projects: 

  • Interaction of Hydroxamic acid derivatives with Histone Deacetylase like protein and DNA: Manipulation of genetic damages an epigenetic level – A hybrid quantum classical approach (QM/MM) in cancer research.
  • Computational studies on inhibition of epigenetic modifications of cancer codes.
  • Fluorescence spectroscopic and molecular docking evidence of non-steroidal anti-inflammatory drugs bind to DNA.
  • Development of fluorescence DNA molecular biomarkers for efficacy assessment of chemotherapy in the treatment of lung cancer.
  • Development of fluorescence probe based on Hydroxamate derivatives for the analysis of fluoride (F-) ions.
  • Development of fluorescence and colorimetric dual sensing immobilized portable molecular probe for spot analysis of selective trace metal ions in an analytical system.
  • Engineering immobilized DNAzyme fluorescence sensors for environmental on-site monitoring of water bodies.
  • Studying the antimicrobial activity of N–arylhydroxamic acid derivatives.
  • Hydroxamic acid derivatives as fluorescence sensors in organized media.
  • Investigation of the competition of HDAC enzyme inhibitors in anti-cancer therapy; SAHA and LQ824 with HDAC1.
  • The development of fluorescence sensor, based on 1, 10-phenanthroline and its derivatives for the analysis of trace metal ions in aquatic system and biological fluids.
  • Experimental and molecular docking studies on DNA binding interaction of some N-arylhydroxamic acid derivatives.
  • In-vitro studies on binding ability of  hydroxamic acid and its derivatives with DNA : Experimental and computational approach.
  • A study on the agricultural runoff and other improper waste disposal degrading the quality of stagnant water bodies in South Eastern Region of Sri Lanka.
Publications:

Full Papers

1)    Mohamed Abdul Cader Mohamed Haniffa, Khadija Munawar, Ching Yern Chee, Sumit Pramanik, Ahmed Halilu, Hazlee Azil Illias, Muhammad Rizwan, Rajendram Senthilnithy, Kariyawasam Ranaweerage Ranjith Mahanama, Ashis Tripathy, Mohd Fahmi Azman, (2021), Cellulose supported magnetic nanohybrids: Synthesis, physicomagnetic properties and biomedical applications-A review, Carbohydrate Polymers 267: 118136.

2)    Priyani Paligaspe, Samantha Weerasinghe, D.P. Dissanayake, R. Senthilnithy, (2021), Identify the effect of As(III) on the structural stability of monomeric PKM2 and its carcinogenicity: A molecular dynamics and QM/MM based approach, Journal of Molecular Structure 1235: 130257.

3)    Ramachandren Dushanan, Samantha Weerasinghe, Dhammike P., Dissanayake & Rajendram Senthilinithy (2020), Cracking a cancer code histone deacetylation in epigenetic: the implication from molecular dynamics simulations on efficacy assessment of histone deacetylase inhibitors, Journal of Biomolecular Structure and Dynamics, (2020), DOI:10.1080/07391102.2020.1838328

4)    Thanippuli Arachchi D. H., Wijesekera, G. I. P., Costa M. D. P. De, Senthilnithy R., Amino and chloro derivatives of 1,10-phenanthroline as turn-off fluorescence sensors for selective and sensitive detection of Fe(II), Journal of Photochemistry & Photobiology A. Chemistry, 402, (2020), 112805.

5)    Senthilnithy R.; Weerasinghe S. and Dissanayake D.P., Interaction of caffeine dimers with water molecules, Computational and Theoretical Chemistry, (2014), 1028, 60-64.

6)    Dissanayake D.P. and Senthilnithy R., Thermodynamic cycle for the calculation of ab-initio pKa values for Hydroxamic Acids, Journal of Molecular Structure: Theochem, (2009), 910, 93-98.

7) Senthilnithy R., Gunawardhana H. D. and Costa M. D. P. De, Fluorescence quenching and bonding properties of some hydroxamic acid derivatives by Fe(III) and Mn(II), The Journal of Biological and Chemical Luminescence: Luminescence, (2009), 24(4), 203-208.

8)    Senthilnithy R., Weerasinghe S. and Dissanayake D.P., Stability of hydroxamate ions in aqueous medium, Journal of Molecular Structure: Theochem, (2008), 851, 109–114.

9)    Dissanayake D.P., Senthilnithy R. and Weerasinghe S., Quantum mechanics and molecular dynamics study on the stability of hydroxamate anion-water clusters, Ceylon Journal of Science, (2008), 14, 53-66.

10)  Senthilnithy R., Gunawardhana H. D. and Costa M. D. P. De, The pKa values of ligands and stability constants of the complexes of Fe(III), Cu(II) and Ni(II) with some hydroxamic acids: A comparative study of three different potentiometric methods, J. Natn. Sci. Foundation Sri Lanka, (2008), 36(3), 191-198.

11)  Senthilnithy R., Gunawardhana H. D., Costa M. D. P. De and Dissanayake D. P.,  Absolute pKa determination for N-phenylbenzohydroxamic acid derivatives, Journal of Molecular Structure: Theochem, (2006), 761, 21-26.

12)  Senthilnithy R., Gunawardhana H. D. and Costa M. D. P. De, In-situ determination of copper(II) and cobalt(II) using adsorptive cathodic stripping voltammetry with hydroxamic acid modified carbon paste electrode, J. Natn. Sci. Foundation Sri Lanka, (2006), 34(4), 189-194.


Presentations at Conferences/Meetings (published as full paper)

 1)   Nawas M. F., Senthilnithy R. and Haniffa MACM, “Impact of Domestic and Other Waste Effluent on Equilibrium of Dissolved Oxygen in Stagnated Water Bodies”, 2nd International Symposium, SEUSL – 2012.

2)   M.A.C.M. Haniffa, R. Senthilnithy, K.R.R. Mahanama; Effect of sodium concentration of inland water bodies related to paddy cultivated land in South Eastern region, Third International Symposium, SEUSL – 2013.

3)   Mohamed Haniffa Mohamed Abdul Cader, Senthilnithy Rajendram, Ranjith Mahanama Kariyawasam, Impact of Urban Drainage on Dynamic Equilibrium of Dissolved Oxygen in Water Bodies of Sri Lanka, 13th International Conference on Urban Drainage, Sarawak, Malaysia, 7-12 September 2014.

4)   Sumaiya, M.A.F.; Safeena, M.I.S.; Senthilnithy, R., “Experimental and molecular docking studies on DNA binding interaction of derivative of N-arylhydroxamic acid“, Proceedings of Sixth International Symposium-2016, South Eastern University of Sri Lanka, 2016.

5)   Jumani, A.L.F; Safeena, M.I.S.; Senthilnithy, R. “A Study of Hydroxamic acid derivative to DNA: Experimental and Computational approach“, Proceedings of 5th Annual Science Research Session, Faculty of Applied Sciences, South Eastern University of Sri Lanka, 2016.

6)   Wickramasinghe G. C., Wickramasinghe W. H. G. S., Perera V. P. S., and Senthilnithy R., Fabrication and Characterization of CuO Nanocrystaline Thin Films Prepared by Using Colloidal Suspension, Vidulka, National Energy Symposium organized by Ministry of Power and Energy, (2019), p. 213-218.

7)   Paligaspe, G. M. P. R., Weerasinghe, S., Dissanayake, D. P., & Senthilnithy, R. (2020). Investigation of the impact of Cd(II) ion on human uracil DNA glycosylase: An in-silicoapproach. Proceedings of the 9th YSF Symposium. 25-30.

8)   Dushanan, R., Weerasinghe, S., Dissanayake, D. P., & Senthilinithy, R. (2020). In-silico investigation of inhibitory efficacy of selected hydroxamic acid derivatives on histone deacetylase enzyme. Proceedings of the 9th YSF Symposium. 19-24.

9)   Wickramasinghe, G. C., Perera, V. P. S., & Senthilnithy, R. (2020). Optical characteristics of cupric oxide prepared by hydrolysis of copper acetate using triethylamine. Proceedings of the 9th YSF Symposium. 115-118.

10)  Wijesekera, G.I.P., Arachchi, D.H.T., De Costa, M.D.P., & Senthilnithy, R. (2020). Protonated 1,10-Phenanthroline as a fluorescent sensor for Fe (II) at micro molar level detections. FITI-2020: SLAAS/SLIC Conference on FROM INNOVATION TO IMPACT, BMICH, Colombo;IEEE; P. 1-6, doi: 10.1109/FITI52050.2020.9424908


Presentations at Conferences/Meetings (published as abstracts)

 1)    R. Dushanan, S. Weerasinghe, D.P. Dissanayake, R. Senthilnithy, In-silico studies on the inhibition of DNA methyltransferase enzyme using (19r)-epimisiline: a compound isolated from Sri Lankan medicinal plant, 7th International Conference on Ayurveda, Unani, Siddha, and Traditional Medicine 2021, ICAUST2021, p. 18.

2)    Paligaspe, G. M. P. R., Weerasinghe, S., Dissanayake, D. P., & Senthilnithy, R. (2020). Identification of the most favorable binding site of PKM2 enzyme for As(III): QM/MM and MD studies. Proceedings of the Open University Research Sessions, OURS2020. 119.

3)    Thanippuli, A. D. H., Costa, M. D. P. De., & Senthilnithy, R. (2020). Effect of pH on the fluorescence quenching of 5-chloro-1, 10 phenanthroline by Fe(II). Proceedings of the Open University Research Sessions, OURS. 121.

4)    Wickramasinghe, G. C., Perera, V. P. S., & Senthilnithy, R. (2020). Synthesis and characterization of nanostructured P-type cuprous oxide using Benedict’s solution. Psroceeding of the Open University Research Sessions, OURS. 126.

5)    Dushanan, R., Weerasinghe, S., Dissanayake, D. P., & Senthilinithy, R. (2020). Inhibition of Histone Deacetylase Like Protein: Insights from computational studies. Proceedings of Annual Research Congress, PGIS RESCON. 189.

6)    Dushanan, R., Weerasinghe, S., Dissanayake, D. P., & Senthilinithy, R. (2020). Effect of HDAC inhibitors on the stability of HDLP enzyme: An in-silico approach. Proceedings of 13th International Research Conference, KDUIRC. 4.

7)    Parthiban, G., Dushanan, R., Weerasinghe, S., Dissanayake, D. P., & Senthilinithy, R. (2020). Manipulation of histone modification using hydroxamic acid derivatives: An implication of Ramachandran plot. Proceedings of 13th International Research Conference, KDUIRC. 22.

8)    Wickramasinghe G. C., Nupearachchi C. N., Perera V. P. S., & Senthilnithy, R. (2020). Enhancement of Photovoltaic Performance of Dye Sensitized Solar Cells by Acidifying of Anthocyanin Containing in Erabadu Dye. Proceedings of 1st International Conference, FICT. 97.

9)    Dushanan, R., Weerasinghe, S., Dissanayake, D. P., & Senthilinithy, R. (2020). QM/MM studies on Inhibition of Histone Deacetylation. Proceedings of 1st International Conference, FICT. 98.

10)  Parthiban, G., Dushanan, R., Weerasinghe, S., Dissanayake, D. P., & Senthilinithy, R. (2020). Interaction of hydroxamic acids derivatives in clinical trial I with HDLP enzyme; An in-silico approach. Proceedings of 1st International Conference, FICT. 100.

11)  Paligaspe, G. M. P. R., Weerasinghe, S., Dissanayake, D. P., & Senthilnithy, R. (2020). A computational study on the impact of As(III) ion on the secondary structure of human-PKM2 enzyme. Proceedings of 1st International Conference, FICT. 127.

12)  Upendra K. B. G. S., Jeyakumaran N., Jayasinghe C. D., Costa M. D. P. De, and Senthilinithy R., A preliminary study on a fluorescence sensor for efficacy assessment of chemotherapy treatment in the lung cancer patients, Proceeding of the Open University Research Sessions OURS- 2019, p. 103-104.

13)  Wijesekera G. I. P., Costa M. D. P. De and Senthilinithy R., Effect of hydrogen bonding on the fluorescence of protonated 1,10 Phenanthroline and 1,10 Phenanthroline-5-amine, Proceeding of the Open University Research Sessions OURS- 2019, p. 105-106.

14)  Wickramasinghe G. C., Wickramasinghe W. H. G. S., Perera V. P. S., and Senthilnithy R., Fabrication and Characterization of CuO Nanocrystaline Thin Films Prepared by Using Colloidal Suspension, Vidulka, National Energy Symposium organized by Ministry of Power and Energy, (2019), p. 213-218

15)  Wijesekera G. I. P, Costa M. D. P. De and Senthilnithy R., Complexation between Fe2+ and 1, 10- Phennanthroline-5-amine and the quenching mechanism, Chemistry in Sri Lanka, (2019), 36-2, 33.

16)  Perera P.P.P., Costa M.D.P.De and Senthilnithy R., A study on the use of Bathophennanthroline as a fluorescence sensor for iron(II), Chemistry in Sri Lanka, (2019), 36-2, 34.

17)  Sahira A. M. F., Safeena M. I. S. and Senthilnithy R., Spectroscopic and molecular docking evidence of diclofenac and mefenamic acid binding to DNA, Proceeding of the  Open University International Research Sessions, (iOURS-2018), p 113-114.

18)  Dewapura K.M.P., Gunaherath G. M. K.B., Costa M. D. P. De and Senthilnithy R., Synthesis of Iron(III)-naphthylacetohydroxymate Complex as Chelation-Enhanced Fluorescence Sensor for Determination of Fluoride Ions: Proceeding of the Open University International Research Sessions, (iOURS-2018), p 101-102.

19)  Opallage P. M., Senthilnithy R. and M. D. P. De Costa, The Behavior of Emissive Phenanthroline-Iron(II) Charge Transfer Complex on Ionic Strength, Chemistry in Sri Lanka, (2018), 35-2, 13.

20)  Opallage P. M., Costa M. D. P. De and Senthilnithy R., Selective Ratiometric Fluorescence Sensor For Determination of Iron(II), International Symposium in Photochemistry; 27th PhotoIUPAC, Dublin 2018.

21)  Dushanan R., Ranawaka G.R., Weerasinghe S. and Senthilnithy R., Computational Studies on Inhibition of Histone Deacetylation by Hydroxamic Acid Derivatives: An In-Silico Approach, Proceeding of the 15th Open University Research Sessions OURS- 2017, p. 461-464.

22)  Sifnas MRR, Safeena MIS and Senthilnithy R, Anti-Microbial Activity of Hydroxamic Acid Derivatives, Annual Science Research Session, FAS/SEUSL-24th November, 2015, p. 32.

23)  Mafasa H, Senthilnithy R. and Safeena MIS, Antimicrobial Activity of N-Phenyllaurohydroxamic Acid and O-Chloro, O-Methyl Derivatives of N-Phenyl benzohydroxamic Acid, Annual Science Research Session, FAS/SEUSL-24th November, 2015, p. 6.

24)  Haniffa MACM, Senthilnithy R. and Mahanama K. R. R, Sodium – Adsorption Ratio in an Inland Agricultural Water Sources: A preliminary Study in South Eastern Region, International Conference on Postcolonial Societies in Transition, March 02-03, 2015, University of Ruhuna, Sri Lanka. (“Sri-Lankas Postcolonial Legacy, 1815-2015”, proceedings; pg. 74.

25)  Haniffa MACM, Senthilnithy R. and Mahanama K. R. R, The Study of the Impact of Agricultural runoff and Improper Waste Disposal on Stagnant Water Bodies in South Eastern Sri Lanka, International Conference on Chemical Education, College of Chemical Sciences (IChem), 3rd & 4th April 2014.

26)  M. A. C. M. Haniffa, R. Senthilnithy and K. R. R. Mahanama, Contribution of Organic Contaminations and Nutrient level on Dynamic Equilibrium of Dissolved Oxygen in Water Bodies of Costal Belt of Ampara District, Fourth International Symposium, SEUSL – 2014.

27)  MACM Haniffa, R Senthilnithy, KRR Mahanama, The Impact of Organic Contamination on the Dynamic Equilibrium of Dissolve Oxygen in Selected Water Bodies in South East Sri Lanka, Proceedings of International Forestry and Environment Symposium proceedings, 2013.

28)  Haniffa MACM, Senthilnithy R. and Mahanama K. R. R, “Pollution on the selected stagnant water bodies South Eastern Sri Lanka”, Seventh International Forestry and Environment Symposium, University of Sri Jayewardenepura – 2012.

29)  Safeena M. I. S. and Senthilnithy R., “Antifungal Activity of N-phenylbenzo- hydroxamic acid Against Mucor sp.”, Annual Science Research Session, FAS/SEUSL-2012.

30)  MF Nawas, R Senthilnithy, MACM Hanifa,“Impact of domestic and other waste effluents on equilibrium of dissolved Oxygen in stagnated water bodies” Second International Symposium, SEUSL – 2012, p. 174-177.

31)  Dissanayake D.P., Senthilnithy R. and Weerasinghe S., “Quantum mechanics and molecular dynamics study on the stability of hydroxamate anion-water clusters”, National Conference on Advanced Materials for Emerging Technologies (NCAMET 2007).

32)  Senthilnithy R., Gunawardhana H. D. and Costa M. D. P. De, “Speciation studies on Cu(II) and Fe(III) complexes of 1-napthalenemethyliminodiaceto hydroxamic acid”, Chemistry in Sri Lanka, (2006), 23-2, 34.

33)  Senthilnithy R., Gunawardhana H. D. and Costa M. D. P. De, “Potentiometric determination of ionization constant of N-arylhydroxamic acid in non-aqueous solvent; a comparative study with spectroscopic method”, Sri Lanka Assoc. Advt. Sci., Proceedings of 61st Annual Session (2005), Part I-Abstracts, 68-69.

34)  Senthilnithy R., Gunawardhana H. D. and Costa M. D. P. De, “Aminodihydroxamic acid derivative of naphthalene as a fluorescence ionophore for iron(III)”, Sri Lanka Assoc. Advt. Sci., Proceedings of 61st Annual Session 2005, Part I-Abstracts, 68.

35)  Senthilnithy R., Gunawardhana H. D. and Costa M. D. P. De, “Determination of pKa value using Electronic Spectroscopy: A modification of available classical method”, Chemistry in Sri Lanka, (2005), 22-2, 22.

36)  Senthilnithy R., Gunawardhana H. D. and Costa M. D. P. De, “Substituent Effects on Isosbestic Points of Charge Transfer Absorption of Metal Ion-Monohydroxamate in Methanol”, Chemistry in Sri Lanka, (2004), 21-2, 18-19.


Posters

1)    Senthilnithy R., Gunawardhana H. D. and Costa M. D. P. De, (2004), Determination of Cu(II) using Chemically Modified Carbon Paste Electrode: An Experiment to Undergraduates. “Chemical Education for National Development”; Silver Jubilee Conference; College of Chemical Sciences; Institute of Chemistry.

2)    Haniffa MACM, Senthilnithy R. and Mahanama K. R. R, (2014), The impact of organic contamination on the dynamic equilibrium of dissolve oxygen in selected water bodies in South East Sri Lanka, 18th International Forestry and Environmental Symposium 2013, University of Sri Jayewardenepura, 10th &11th January 2014. Abstract published in the Proceeding Part I, P-9, page 136.

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